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KMID : 0918520220220020053
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Journal of the Korean Society of Inherited Metabolic Disease
2022 Volume.22 No. 2 p.53 ~ p.57
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Congenital Metabolic Disorders with Cutaneous Changes
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Lee Sang-Eun
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Abstract
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Congenital metabolic disorders are rare inherited disorders resulting from a defect in biochemical and metabolic pathways affecting proteins, fats, carbohydrates metabolism or impaired organelle function. Depending on the abnormality of biochemical metabolism, various precursors and their abnormal metabolites can accumulate in the body and the final products which are critical in normal physiology can be deficient, resulting in disease. Congenital metabolic disorders present complicated medical conditions involving several human organ systems, including nervous system, eyes, liver, and kidneys. Various proteins and lipids are involved in the development and homeostasis of the skin, so many congenital metabolic disorders present abnormal changes in skin and hair. In this review, congenital metabolic diseases related to amino acid and lipid metabolism accompanying skin abnormalities will be discussed.
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KEYWORD
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Congenital metabolic disorders, Skin, Hair, Amino acid, Lipid
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